Comparison of two software programs to be used for the calculation of population pharmacokinetic parameters
Identifieur interne : 002388 ( Main/Exploration ); précédent : 002387; suivant : 002389Comparison of two software programs to be used for the calculation of population pharmacokinetic parameters
Auteurs : Cees Neef [Pays-Bas] ; Roger W. Jelliffe [États-Unis] ; Teus Van Laar [Pays-Bas] ; Tineke Loohuis [Pays-Bas] ; A. W. Guus Essink [Pays-Bas] ; Ernst N. H. Janssen [Pays-Bas]Source :
- International Journal of Bio-Medical Computing [ 0020-7101 ] ; 1994.
Abstract
The pharmacokinetic parameters of apomorphine, a potent dopamine agonist, were calculated after subcutaneous and intranasal administration. Two available software packages for TDM were used (USC ∗ PACK and MW/PHARM). The findings for the calculated parameters Kel, Vslope, Ka and bioavailability were compared. Although small, sometimes significant differences were found, the NPEM program from the USC ∗ PACK collection provides most information about the population under investigation. We found a median Vslope of 1.7408 ± 0.8461 (S.D.) 1/kg, and a mean Kel of 1.5341 ± 0.3748 h−1. The absorption after intranasal administration was extremely rapid: Ka = 20.5 ± 1.96 h−1, comparable with that found with subcutaneous absorption: Ka = 23.04 ± 2.20 h−1.
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DOI: 10.1016/0020-7101(94)90107-4
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Box 50000, 7500 KA Enschede</wicri:regionArea><wicri:noRegion>7500 KA Enschede</wicri:noRegion></affiliation></author><author><name sortKey="Loohuis, Tineke" sort="Loohuis, Tineke" uniqKey="Loohuis T" first="Tineke" last="Loohuis">Tineke Loohuis</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Pharmacy, Medisch Spectrum Twente, P.O. Box 50000, 7500 KA Enschede</wicri:regionArea><wicri:noRegion>7500 KA Enschede</wicri:noRegion></affiliation></author><author><name sortKey="Guus Essink, A W" sort="Guus Essink, A W" uniqKey="Guus Essink A" first="A. W." last="Guus Essink">A. W. Guus Essink</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Rijnstate Hospital, Department of Clinical Pharmacy, P.O. Box 9555, 6800 TA Arnhem</wicri:regionArea><wicri:noRegion>6800 TA Arnhem</wicri:noRegion></affiliation></author><author><name sortKey="Janssen, Ernst N H" sort="Janssen, Ernst N H" uniqKey="Janssen E" first="Ernst N. H." last="Janssen">Ernst N. H. Janssen</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Medisch Spectrum Twente, P.O. Box 50000, 7500 KA Enschede</wicri:regionArea><wicri:noRegion>7500 KA Enschede</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Bio-Medical Computing</title><title level="j" type="abbrev">IJBOLD</title><idno type="ISSN">0020-7101</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">36</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="143">143</biblScope><biblScope unit="page" to="150">150</biblScope></imprint><idno type="ISSN">0020-7101</idno></series><idno type="istex">FB5BA4417268E1448D985E5AF7B4192E92E15DBF</idno><idno type="DOI">10.1016/0020-7101(94)90107-4</idno><idno type="PII">0020-7101(94)90107-4</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0020-7101</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pharmacokinetic parameters of apomorphine, a potent dopamine agonist, were calculated after subcutaneous and intranasal administration. Two available software packages for TDM were used (USC ∗ PACK and MW/PHARM). The findings for the calculated parameters Kel, Vslope, Ka and bioavailability were compared. Although small, sometimes significant differences were found, the NPEM program from the USC ∗ PACK collection provides most information about the population under investigation. We found a median Vslope of 1.7408 ± 0.8461 (S.D.) 1/kg, and a mean Kel of 1.5341 ± 0.3748 h−1. The absorption after intranasal administration was extremely rapid: Ka = 20.5 ± 1.96 h−1, comparable with that found with subcutaneous absorption: Ka = 23.04 ± 2.20 h−1.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Los Angeles</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Neef, Cees" sort="Neef, Cees" uniqKey="Neef C" first="Cees" last="Neef">Cees Neef</name></noRegion><name sortKey="Guus Essink, A W" sort="Guus Essink, A W" uniqKey="Guus Essink A" first="A. W." last="Guus Essink">A. W. Guus Essink</name><name sortKey="Janssen, Ernst N H" sort="Janssen, Ernst N H" uniqKey="Janssen E" first="Ernst N. H." last="Janssen">Ernst N. H. 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